VIVITROL IS AN ANTAGONIST OR BLOCKING MEDICATION1-3

Antagonists create a barrier that blocks opioid molecules from attaching to opioid receptors. Antagonists attach to opioid receptors, but do not cause the release of dopamine. They are non-addictive and do not lead to physical dependence. VIVITROL blocks opioid receptors in the brain for one month at a time, helping patients to prevent relapse to opioid dependence, following opioid detox, while they focus on counseling. Patients must be opioid-free before starting VIVITROL.

Excessive stimulation of the dopamine reward system is blocked.

VIVITROL is an antagonist that blocks opioid molecules from attaching to opioid receptors.

VIVITROL is not right for everyone. There are significant risks from VIVITROL treatment, including risk of opioid overdose, severe reaction at the injection site and sudden opioid withdrawal.
See Important Safety Information below. Discuss all benefits and risks with a healthcare provider. See Prescribing Information and Medication Guide.


References:

  1. Kosten TR, George TP. The neurobiology of opioid dependence: implications for treatment. Sci Pract Perspect. 2002;1(1):13-20.
  2. VIVITROL [prescribing information]. Waltham, MA: Alkermes, Inc; rev December 2018.
  3. Krupitsky E, Nunes EV, Ling W, Illeperuma A, Gastfriend DR, Silverman BL. Injectable extended-release naltrexone for opioid dependence: a double-blind, placebo-controlled, multicentre randomised trial. Lancet. 2011;377(9776):1506 -1513.
*Eligibility for Alkermes-Sponsored Co-pay Assistance: Offer valid only for prescriptions for FDA-approved indications. You must be at least 18 years old. If you are purchasing your VIVITROL® prescriptions with benefits from Medicare, including Medicare Part D or Medicare Advantage plans; Medicaid, including Medicaid Managed Care or Alternative Benefit Plans (“ABPs”) under the Affordable Care Act; Medigap; Veterans Administration (“VA”); Department of Defense (“DoD”); TriCare®; or any similar state funded programs such as medical or pharmaceutical assistance programs, you are not eligible for this offer. Void where prohibited by law, taxed or restricted. Subject to plan benefit design requirements. Alkermes, Inc. reserves the right to rescind, revoke or amend these offers without notice.