Adherence

A month of medication provided in a single dose

Adherence to any treatment program is essential for a successful outcome.6

VIVITROL overcomes the limitations of daily oral dosing

VIVITROL is administered once monthly or every 4 weeks, which means your patients don't have to remember to take daily oral medications to treat their alcohol dependence.

As a once-a-month treatment, VIVITROL relieves your patients of the burden of daily adherence decisions by shifting daily dosing responsibility from your patients to the unique drug-delivery system.

It is important to recognize that a long-term commitment is a critical component of recovery. This commitment requires your patients' regular participation in your counseling and/or treatment program.

Figure 1 compares VIVITROL 380 mg to daily dosing with oral naltrexone.

Figure 1.

*Data for oral naltrexone beyond day 5 have been extrapolated from a study of normal healthy volunteers (n=14) given oral naltrexone 50 mg daily for days.2

This was a head-to-head study comparing the pharmacokinetics of oral naltrexone to VIVITROL.2

• The peaks and troughs associated with daily oral naltrexone administration may diminish efficacy, increase adverse effects, and reduce compliance1
• In contrast, VIVITROL provides more consistent and measurable naltrexone plasma levels over a one month period, as shown above in Figure 1
• With VIVITROL 380 mg, naltrexone plasma concentrations reach a transient initial peak approximately 2 hours after injection, followed by a second peak approximately 2 to 3 days later. Beginning approximately 14 days after dosing, concentrations slowly decline, with measurable levels for greater than 1 month
• Steady state is achieved by the second dose7