No. You may remove the carton from the refrigerator prior to the patient's arrival, but once the diluent is added to the VIVITROL Microspheres, the dose should be mixed and the suspension administered immediately. It is very important to use proper aseptic technique when preparing the suspension. VIVITROL must be administered by a healthcare professional.

It is recommended that the suspension be administered immediately once the product has been suspended and transferred into the syringe. If a few minutes' delay occurs after suspension but before transfer into the syringe, the vial can be inverted a few times to resuspend and then transferred into the syringe for immediate use.

VIVITROL must be suspended only in the diluent supplied in the carton and must be administered with the needle supplied in the carton. All components (ie, the microspheres, diluent, preparation needle, and an administration needle with safety device) are required for administration. A spare administration needle is provided in case of clogging. Do not substitute any other components for the components of the carton.

Yes. VIVITROL Microspheres will form a milky white suspension when mixed with the provided diluent.

If a clog occurs during administration, the needle should be withdrawn from the patient, capped with the attached safety device, and replaced with the spare administration needle provided. Gently push on the plunger until a bead of the suspension appears at the tip of the needle. The remainder of the suspension should then be administered into an adjacent site in the same gluteal region.

If a patient misses a dose, he/she should be instructed to receive the next dose as soon as possible. There are no data to specifically address the reinitiation of treatment in a patient who has previously discontinued treatment.